Bait and switch: synthetic GEFs divert an input signal to diverse cellular responses.
نویسنده
چکیده
The Rho family GTPases regulate many cellular functions including the organization, mechanics, and dynamics of the actin cytoskeleton. Re-engineering the highly conserved autoinhibitory structure of GEFs, Yeh et al. (2007) generated novel synthetic proteins that regulated Rho GTPase signaling and cell morphology, highlighting the power of protein module engineering.
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عنوان ژورنال:
- Developmental cell
دوره 13 1 شماره
صفحات -
تاریخ انتشار 2007